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Ini terjadi selama respon imun primer ketika sistem kekebalan tubuh pertama kali terkena antigen tertentu. [ four ]Pertahanan pelindung sistem kekebalan tubuh bawaan dimulai dengan hambatan anatomi seperti kulit utuh dan selaput lendir yang mencegah masuknya banyak mikroorganisme dan agen beracun. Kulit juga memiliki lingkungan asam pH three-five y